Table 2.
Crude Incidence Rates and Adjusted Hazard Ratios for Hospitalization With Infection, by Cardiovascular Disease Status, ARIC Study, 1996–2013
| Exposure Status | No. of Participants | No. of Events | Incidence Rate per 1,000 Person-Years | 95% CI | Adjusted Hazard Ratio | 95% CI |
|---|---|---|---|---|---|---|
| Overall sample | ||||||
| No prevalent CVD at baseline | 8,337 | 3,187 | 29.9 | 28.9, 31.0 | 1.00 | Referent |
| Prevalent CVD at baseline | 1,066 | 576 | 53.4 | 49.2, 57.9 | 1.31 | 1.19, 1.45 |
| Persons without prevalent CVD at baseline | ||||||
| hs-cTnT concentration | ||||||
| Categorical variable, ng/L | ||||||
| <3 | 3,401 | 1,114 | 24.1 | 22.7, 25.5 | 1.00 | Referent |
| 4–5 | 1,717 | 647 | 28.8 | 26.7, 31.1 | 1.10 | 0.99, 1.21 |
| 6–8 | 1,687 | 683 | 32.5 | 30.2, 35.1 | 1.14 | 1.03, 1.26 |
| 9–13 | 1,028 | 480 | 40.3 | 36.9, 44.1 | 1.28 | 1.14, 1.44 |
| ≥14 | 504 | 263 | 52.8 | 46.8, 59.6 | 1.44 | 1.24, 1.69 |
| Continuous variable, per log(hs-cTnT) | 1.21 | 1.13, 1.29 | ||||
| NT-proBNP concentration | ||||||
| Categorical variable, pg/mL | ||||||
| <48.1 | 3,378 | 1,172 | 26.1 | 24.6, 27.6 | 1.00 | Referent |
| 48.1–80.1 | 1,712 | 630 | 28.3 | 26.2, 30.6 | 1.04 | 0.94, 1.15 |
| 80.2–137.1 | 1,691 | 677 | 31.5 | 29.3, 34.0 | 1.15 | 1.04, 1.27 |
| 137.2–248.0 | 1,034 | 433 | 34.5 | 31.4, 37.9 | 1.19 | 1.06, 1.34 |
| ≥248.1 | 522 | 275 | 51.2 | 45.5, 57.7 | 1.57 | 1.35, 1.81 |
| Continuous variable, per log(NT-proBNP) | 1.09 | 1.05, 1.13 |
Abbreviations: ARIC, Atherosclerosis Risk in Communities; CI, confidence interval; CVD, cardiovascular disease; hs-cTnT, high-sensitivity cardiac troponin T; NT-proBNP, N-terminal pro-B-type natriuretic peptide.