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. 2020 Apr 30;10:452. doi: 10.3389/fonc.2020.00452

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Copyright © 2020 Yousefnia, Seyed Forootan, Seyed Forootan, Nasr Esfahani, Gure and Ghaedi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Role of CD24 and CD44 in inhibition and promotion of BCSCs, respectively. CD24 inhibits stemness phenotypes of BCSCs through inhibition of STAT1 and SHH. However, CD44 promotes chemotherapy resistance and invasion of BCSCs through CD44–PKC_ε-Nanog signaling axis and inducing c-Jun signaling.