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Activation of repair mechanisms due to radiotherapy induced-damages in BCSCs. DNA damage induced by radiotherapy is repaired through an ATM–ZEB1–CHK1 signaling axis. Activated ATM and ATR kinases phosphorylate ZEB1. ZEB1 interacts with USP7, a deubiquitylating enzyme, and promotes the deubiquitylation ability of USP7 that stabilizes CHK1.
