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. 2020 Apr 29;11:423. doi: 10.3389/fgene.2020.00423

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Copyright © 2020 Chen, Chen, Yuan, Xu, Yang, Li, Shen and Yin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Data preprocessing of the derivation cohort. Box plot and principal component analysis showing the overall profiles of GSE112366 and GSE75214 (A,B) before and (C,D) after normalization. The results confirmed removal of the batch effect PCA.