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. 2020 Apr 29;11:423. doi: 10.3389/fgene.2020.00423

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Copyright © 2020 Chen, Chen, Yuan, Xu, Yang, Li, Shen and Yin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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DEGs identified in the derivation cohort. (A) Volcano plot of DEGs. Red dots represent relatively upregulated genes and green dots represent downregulated genes. Black dots represent genes showing no significant alteration. There were 150 DEGs, including 70 upregulated and 80 downregulated genes among 17,689 genes. Bubble plot of (B) Gene Ontology and (C) KEGG enrichment analyses. (D) Cytoscape software was used for the analysis. (E) Hub genes with the top 15 degrees of interaction were identified using Cytohubba plugin. (F) Heatmap of the hub genes. BP, biological process; CC, cellular component; MF, molecular function.