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. 2020 Apr 23;11:380. doi: 10.3389/fphys.2020.00380

Figure 3.

Figure 3

Subnetworks representing the effect of exogenous cytokines on cell differentiation. Exogenous IL-4, IL-2, IFNγ, IL-10, TGF-β, and IL-21 were herein named IL-4e, IL-2e, IFNGe, IL-10e, TGFBe, and IL-21e (polygons). Specific cytokines induce the activity of particular transcription factors (T-bet, GATA3, RORγt, and Foxp3), which guide the differentiation of effector cell subtypes (Th1, Th2, and Treg cells produce IFNγ, IL-4, and TGF-β, respectively, whereas Th17 cells produce IL-21 and IL-17). Cross-inhibitory signals involved in the predominant induction of a cell subtype by particular cytokines are shown. Colors of rectangles correspond to the type of components, as indicated in Figure 1.