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. 2020 Apr 23;11:380. doi: 10.3389/fphys.2020.00380

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Copyright © 2020 Martínez-Méndez, Villarreal, Mendoza and Huerta.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Time-dependent activity of CD80/86 due to the shift of its relative affinity for CD28 and CTLA-4 dimers. The magenta curve describes the linkage strength of the CD80/86-CD28 complex which shows a steep decrease at t_d ≃ 10. The green curve describes the anticorrelated behavior of the linkage strength of CD80/86-CTLA-4 dimers complex.