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. 2020 Apr 28;11:445. doi: 10.3389/fphys.2020.00445

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Copyright © 2020 Yamada, Ashida, Tatebayashi, Abe and Himori.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cancer cachexia exacerbates atrophy in denervated mouse skeletal muscles. Photographs of anesthetized control (CNT) and cancer cachexia (CCX) mice (A). Images after mouse laparotomy in CNT (B) and CCX mice (C). Note that CCX mice showed extensive intraperitoneal tumor growth (dotted circle). The body (D) and heart (E) weight in each group. Bars show the mean and SEM results from 6 to 7 mice per group. ^§P < 0.05 vs. CNT. The muscle wet weight of fast-twitch gastrocnemius (F) and plantaris muscles (G) and slow-twitch soleus muscles (H) from CNT and CCX mice, with or without denervation (DEN). Bars show the mean and SEM results from 6 to 7 muscles per group. Statistical significance was set at P < 0.05: main effect of ^aCCX and ^bDEN; ^cinteraction of CCX and DEN; difference vs. *CNT without DEN, ^#CNT with DEN, and ^†CCX without DEN.