TABLE 1.

Representative progresses on protein self-assembly through designed supramolecular interactions.

Proteins	Chaperone	Interfacial interactions	Superstructures	Application fields	References
Heme-decorated cyt b562	n.a. or trigeminal hemes	Heme-pocket	Linear or hyperbranched protein necklace	n.a	Kitagishi et al., 2009; Oohora et al., 2018
SAv and dimeric apoMb	heme−bis (biotin)	Heme-pocket and biotin-avidin	Alternating protein nanowires	n.a	Oohora et al., 2012
Lectin (Con A or Lec A)	Rh3Man or Rh3Gal	Sugar-lectin and RhB dimerization	Nanoribbons, nanowires, nanosheets, or superlattices	n.a	Sakai et al., 2014; Yang et al., 2017
Lectin (SBA)	GN3R, M3P, …	Sugar-lectin and dimerization	Helical polymorphism of microtubes	n.a	Li X.M. et al., 2019
FGG-tagged GST	CB[8]	Host-guest	Protein nanowires, nanorings, nanospirals, nanowires, and superwires	Artificial GPx nanoenzyme	Hou et al., 2013; Li et al., 2017
FGG-recoverin-GST fusion	CB[8]	Host-guest	Ca2+ responsive dynamic nanospring	n.a	Si et al., 2016
Microtubules	β−CD and AAP	Host-guest	Photo-controlled reversible assembly	Diseases related to improper protein aggregation	Zhang et al., 2018
SP1 protein	QDs, PAMAM, and CCMs	Electrostatic interactions	Programmed protein nanowires	Chloroplast mimics, Multienzyme cascades	Sun et al., 2015, 2016a
TMV	Pc	Electrostatic interactions	Fibrous bundles	light−mediated heterogeneous catalysis	Anaya-Plaza et al., 2019
CCMV and Ferritin	AuNPs, PAMAM, and Avidin	Electrostatic interactions	Protein superlattices with tunable structures	Active enzyme capture and artificial chaperone activity	Chakraborti et al., 2019
His-tagged GST	Ni2+ ions	Ni2+-His coordination	Protein nanowires or nanorings	n.a	Bai et al., 2013
cyt b562 variant	Ni2+ ions	Ni2+-His coordination	Nanocages, nanotubes, and sheets	n.a	Brodin et al., 2014
Bpy-decorated AAC	Ni2+ ions	Ni2+-bpy coordination	Protein rods and planes	n.a	Yang and Song, 2019
GroELMC	Mg2+ ions	Mg2+-MC coordination	High-integrity nanotubes	ATP-regulated drug delivery	Biswas et al., 2013
His-TMV mutant	Cu2+ ions	Cu2+-His coordination	Highly-porous 2D crystals	Template for inorganic nanoparticle assembly	Zhang et al., 2019
KDPGal/FkpA fusion	n.a	Multiple interfacial interactions	Hexahedral cages	n.a	Lai et al., 2014
AcpS variant	n.a	Multiple interfacial interactions	Dodecameric tetrahedron and tetraicosameric octahedron	n.a	King et al., 2012
Pentamer, trimer or dimer	n.a	Multiple interfacial interactions	Rhombic triacontahedron	Two-component structures	Bale et al., 2016
PNIPAAm-conjugated BSA	n.a	Amphiphilic interfaces	Proteinosomes	Artificial prokaryotic cells	Huang et al., 2013
Polypeptide-conjugated AKe	n.a	Amphiphilic interfaces	Ap5A regulated nanofilaments and rectangular nanosheets	n.a	Xu et al., 2019