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. 2020 Apr 17;8:345. doi: 10.3389/fbioe.2020.00345

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Copyright © 2020 Jimi, Jaguparov, Nurkesh, Sultankulov and Saparov.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Biological activity of growth factors released from the cryogel. (A) Inhibition of mouse mammary gland cell line (NMuMG) proliferation by the cryogel released TGF-β, (B) Stimulation of mouse mast cell line (MC/9) proliferation by the cryogel released IL-10, (C) Stimulation of human umbilical vein endothelial cells (HUVEC) proliferation by the cryogel released VEGF, (D) Decrease in the wound area by the cryogel released FGF. (E) Representative images of wound areas quantified in (D). Data were analyzed using one-way ANOVA with Bonferroni’s multiple comparisons test. **P < 0.01, ***P < 0.001, ****P < 0.0001 compared with the control group.