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. 2020 Apr 17;8:345. doi: 10.3389/fbioe.2020.00345

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Copyright © 2020 Jimi, Jaguparov, Nurkesh, Sultankulov and Saparov.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Wound healing after treatment with cryogel. After total skin excision in mice, an internal splint model was performed, and the mice were divided into four groups by wound treatment: treated with cryogel alone, cryogel plus IL-10/TGF-β, cryogel plus VEGF/FGF, and cryogel plus all growth factors/cytokines (GF/C). Changes in wound area (% vs. day 0) over time are shown. Wound areas in the group with cryogel plus GF/C significantly decreased on days 7 and 10 as compared to the other groups. Values: mean ± SE. ***P < 0.01 compared to other groups, *P < 0.05 compared to cryogel alone group.