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. 2020 Apr 17;8:345. doi: 10.3389/fbioe.2020.00345

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Copyright © 2020 Jimi, Jaguparov, Nurkesh, Sultankulov and Saparov.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Wound healing progression. At the site of skin wounding, granulation tissue developed. This reaction aims to initiate neovascularization to supply blood derived factors as well as oxygen and nutrients, to regenerate epithelium. During granulation development accompanied with deposition of collagen fibers, granulation tissue acts as a scaffold for cell migration and proliferation. Newly formed vessels derived from the fascia and/or EPCs migrate in an upward direction in the granulation. Connected vessels finally reach the site at which epithelial regeneration take place. This process advances in the order of no treatment < cryogel alone < cryogel plus GF/C as demonstrated in the present study.