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. 2020 Apr 23;106(5):717–725. doi: 10.1016/j.ajhg.2020.04.001

Figure 5.

Figure 5

Loss of Cdk8 Caused a Severe Synapse Loss in Larval NMJs

(A) Representative images of larval NMJs of each genotype (Control, elav > luciferase RNAi [top]; Cdk8 loss, elav > Cdk8 RNAi;UAS-LacZ [middle]; and rescued flies, elav > Cdk8 RNAi;UAS-CDK19 reference [bottom]).

(B) Quantification of the number of total boutons in NMJs (n = 14 [control], n = 23 [Cdk8 loss], n = 25 [rescued flies]). Statistical analyses were performed via one-way ANOVA followed by a Tukey post-hoc test. Results are means ± SEM, ∗∗∗p < 0.001.

(C) Quantification of the length of boutons of NMJs (n = 14 [control], n = 23 [Cdk8 loss], n = 25 [rescued flies]). Statistical analyses were performed via one-way ANOVA followed by a Tukey post-hoc test. Results are means ± SEM, n.s., not significant.