. Author manuscript; available in PMC: 2020 May 11.

Published in final edited form as: Nat Rev Clin Oncol. 2020 Feb 13;17(5):300–312. doi: 10.1038/s41571-019-0316-z

Table 3 |.

Clinical features predictive of overall survival benefit

Feature	Median OS
*Upfront*
Age	Inconsistent predictive value^3,33
Gender	Not predictive^3,33
Performance status	Inconsistent predictive value^3,33
LDH	Not predictive³³
CNS metastasis	Inconsistent predictive value^3,33
Liver metastasis	Possibly predictive^3,33
*First-line maintenance*
Best response to induction	Not predictive⁴¹
Age	Inconsistent predictive value⁴¹
Gender	Not predictive⁴¹
Performance status	Not predictive⁴¹
LDH	Not predictive⁴¹
Liver metastasis	Not predictive⁴¹
Previous PCI	Not predictive⁴¹
Time from induction chemotherapy	Inconsistent predictive value⁴¹
*Second line or later*
Platinum sensitivity	Inconsistent predictive value^43,45
Previous lines of therapy	Not predictive⁵
Gender	Not predictive^43,45
Performance status	Not predictive^43,45
LDH	Inconsistent predictive value⁴³
CNS metastasis	Not predictive⁴³
Liver metastasis	Possibly predictive⁴³
Ethnicity	Not predictive⁴³
Stage at diagnosis	Not predictive^43,45

CNS, central nervous system; LDH, lactate dehydrogenase; OS, overall survival; PCI, prophylactic cranial irradiation.