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. Author manuscript; available in PMC: 2020 May 11.
Published in final edited form as: Glia. 2019 Jul 3;67(10):1933–1957. doi: 10.1002/glia.23671

FIGURE 9.

FIGURE 9

Drosophila RNAseq identifies conserved targets and essential pathways in α-synucleinopathy pathogenesis. Mammalian orthologs of Drosophila genes were identified using DRSC Integrative Ortholog Prediction Tool. Orthologs have a ranked score from 1 to 14 indicating the degree of conservation (with 14 being the best). Orthologs that have been previously reported in MSA transcriptomic studies or in human α-synucleinopathy genome wide association studies (GWAS) or whole exome sequencing (WES) studies are shown. The type of evidence is indicated by the color of the circle. Human genetics, human α-synucleinopathy GWAS or WES; Human expr, expression is changed in human MSA patients; Model org expr, expression is changed in a mouse model of MSA; Cell culture expr, expression is changed in a rat oligodendrocyte model of MSA. Orthologs fall into nine pathways of known relevance to human α-synucleinopathies