TABLE 5.
Fatty acid metabolism and peroxisome genes reduced in Both:Control
| Gene | GO notes | Best human ortholog |
|---|---|---|
| Cyp6a18 | Oxygenase | TBXAS1 |
| eloF | Fatty acid elongation/acyltransferase | ELOVL1 |
| CG16904 | Fatty acid elongation/acyltransferase | ELOVL7 |
| Cyp4g1 | Oxygenase | CYP4V2 |
| Uro | Uricase | Nonea |
| CG6690 | Oxidase | QSOX2 |
| CG17560 | Fatty acyl-CoA reductase, localizes to peroxisome | FAR2 |
| CG10097 | Fatty acyl-CoA reductase, localizes to peroxisome | FAR2 |
| CG17562 | Fatty acyl-CoA reductase, localizes to peroxisome | FAR2 |
| CG5103 | None | |
| CG15531 | SCD | |
| CG13091 | Fatty acyl-CoA reductase, localizes to peroxisome | FAR2 |
| CG9458 | Fatty acid elongation/acyltransferase | ELOVL7 |
| CG5122 | Acetyltransferase, acyltransferase, localizes to peroxisome | CRAT |
| CG6432 | Dehydrogenase | ACSS3 |
| CG9459 | Fatty acid elongation/acyltransferase | ELOVL7 |
| Elo68alpha | Fatty acid elongation/acyltransferase | ELOVL4 |
| CG8517 | Oxidoreductase | None |
| CG31413 | Oxidase | QSOX2 |
| Cyp312a1 | Oxygenase | CYP4B1, CYP4F11, CYP4F22, CYP4F12 |
| CG4020 | Fatty acyl-CoA reductase, localizes to peroxisome | FAR1 |
| CG10096 | Fatty acyl-CoA reductase, localizes to peroxisome | FAR2 |
| CG17843 | QSOX2 | |
| CG9314 | Peroxidase, localizes to peroxisome | CAT |
| CG34172 | Oxidase | COX7A1 |
| Gld | CHDH | |
| CG8630 | SCD | |
| Se | GSTO1 | |
| Lsp1beta | Oxidase, Oxygenase | None |
a
Mouse ortholog is urate oxidase. This gene has been inactivated in humans due to mutation. Lack of the enzyme means that urate is the end product of purine metabolism in humans and represents a major antioxidant, with lower urate levels serving as a potential biomarker of Parkinson’s disease (Cipriani, Chen, & Schwarzschild, 2010).