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. 2020 May 11;11:174. doi: 10.1186/s13287-020-01616-8

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 8 — Efficacy of hWJ-MSC in mouse skin wound closure. a Gross view of mouse excisional wound splinting model after transplantations of control vehicle medium (sham), PBS, hucMSC-CM, hucMSC-dp-Ex, hucMSC-Ex, or hucMSC at day 0, days 7, and day 14. b H&E staining of wound sections treated with PBS, hucMSC-CM, hucMSC-dp-Ex, hucMSC-Ex, and hucMSC at days 7 and 14 after the operation. N, normal region; W, wound region. Scale bar = 200 μm. c Wound measurement in each mouse group; n = 6 per group. *P < 0.05 for treatment with hucMSC-CM, hucMSC-Ex, and hucMSC vs. PBS; *P > 0.05 for sham and hucMSC-dp-Ex vs. PBS at days 7 and 14. d Proportion of histological wound healing; n = 6 per group. *P < 0.05 for treatment with hucMSC-CM, hucMSC-Ex, and hucMSC vs. PBS; *P > 0.05 for sham and hucMSC-dp-Ex vs. PBS at days 7 and 14