Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 May 11;21:108. doi: 10.1186/s13059-020-02024-0

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 5 — Gene expression changes of fusion proteins do not phenocopy that of either parent protein. a, d Venn diagrams showing comparison of deregulated gene expression by CTCFL, LCL, and CLC in the presence (a) and absence (d) of endogenous CTCF. b, c, e, f Volcano plot representation of differentially expressed genes in untreated (U) versus LCL (b, e) and CLC (c, f) expressing mESCs in the presence (D) (b, c) and absence (ID) (e, f) of endogenous CTCF. Red and blue mark the genes with significantly increased or decreased expression, respectively (FDR < 0.01). The x-axis shows the log2 fold-changes in expression and the y-axis the log 10 (false discovery rate) of a gene being differentially expressed. The number of genes that are significantly up- or downregulated is indicated in either case