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H2O2-induced cell death in OXPHOS conditions involves MPT. WT and OPA1 variant cells were treated with 250, 500, and 750 μm H2O2 in OXPHOS conditions in the presence and absence of 1 μm CsA for 18 h, and cell death was evaluated by LDH assays. CsA treatment decreased cell death most prominently in OPA1-v1ΔS1 cells. n = 4–9. One-way ANOVA was performed. Error bars, S.E. Note that LDH release of OPA1-KO cells was markedly higher than other cells, although assay values vary greatly.
