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. 2020 Apr 2;295(19):6721–6740. doi: 10.1074/jbc.RA120.012710

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© 2020 Carey et al.

Published under exclusive license by The American Society for Biochemistry and Molecular Biology, Inc.

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Figure 4. — A. fumigatus CM activates PAR-2–dependent calcium responses in A549 airway cells. a, representative calcium traces in response to A. fumigatus CM (strain 1022) diluted 1:4 in HBSS (gray). Also shown are responses to media only (black), CM + 100 μm FSLLRY-NH₂ (green), CM + 100 μm AZ3451 (pink, top graph), or CM after heat treatment (100 °C for 20 min; pink, bottom graph). b, peak responses from independent experiments (n = 6–8) as shown in a. Significance was determined by one-way ANOVA with Bonferroni post-test; **, p < 0.01. c, representative calcium traces in response to dialyzed A. fumigatus CM (strain 1022 or 13073 as indicated) shown in green. Also shown are responses to dialyzed CM in the presence of FSLLRY-NH₂ (pink, top and middle graphs) or CM after heat treatment (pink, bottom graph). d, peak responses from independent experiments (n = 6–8) as shown in c. Significance was determined by one-way ANOVA with Dunnett's post-test comparing all values to dialyzed media alone; **, p < 0.01.