Figure 7.

ODC inhibition increases sensitivity of TNBC cells to doxorubicin. A and B, viability measured by propidium iodide uptake following 72-h pre-treatment with 1 mm DFMO or vehicle and 72-h exposure to doxorubicin in the presence of (A) DFMO or vehicle in TNBC and (B) non-TNBC cells (n = 3); p value by paired two-tailed t test. C, percent change doxorubicin IC₅₀ for DFMO over vehicle control from Fig. 6A and Fig. 7, A and B; IC₅₀ calculated by four parameter logistic nonlinear curve fit. All error bars represent S.E. *, p < 0.05 by unpaired two-tailed t test.