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. 2020 May 11;27:63. doi: 10.1186/s12929-020-00658-7

Table 1.

MicroRNAs involve in hypoxia-mediated human diseases

MicroRNA(s) Change in expression Regulatory gene(s) Disease(s)
miR-18a Up BDNF Myocardial infarction
miR-21 Up

PDCD4

Spry1

Heart failure

Heart failure

miR-22

miR-34a

Up SIRT1 Hypertrophy
miR-98 Down DAPK1 Ischemia/reperfusion
miR-134 Up NOS3 Ischemia/reperfusion

miR-135a

miR-203

Down

Down

PTP1B

Ischemia/reperfusion

Myocardial infarction

miR-144 Down FOXO1 Ischemia/reperfusion
miR-146a-5p Up XIAP Intermittent hypoxia
miR-210 Up

EFNA3

PTP1B

HIF-3α

Vascular remodeling
miR-327 Up CRD Ischemia/reperfusion
miR-340-5p Down Act1 Ischemia/reperfusion
miR-374a-5p Down MAPK6 Ischemia/reperfusion
miR-429 Down MO25 Ischemia/reperfusion
miR-1192 Down CASP3 Myocardial infarction