Table 1.
MicroRNAs involve in hypoxia-mediated human diseases
| MicroRNA(s) | Change in expression | Regulatory gene(s) | Disease(s) |
|---|---|---|---|
| miR-18a | Up | BDNF | Myocardial infarction |
| miR-21 | Up |
PDCD4 Spry1 |
Heart failure Heart failure |
|
miR-22 miR-34a |
Up | SIRT1 | Hypertrophy |
| miR-98 | Down | DAPK1 | Ischemia/reperfusion |
| miR-134 | Up | NOS3 | Ischemia/reperfusion |
|
miR-135a miR-203 |
Down Down |
PTP1B |
Ischemia/reperfusion Myocardial infarction |
| miR-144 | Down | FOXO1 | Ischemia/reperfusion |
| miR-146a-5p | Up | XIAP | Intermittent hypoxia |
| miR-210 | Up |
EFNA3 PTP1B HIF-3α |
Vascular remodeling |
| miR-327 | Up | CRD | Ischemia/reperfusion |
| miR-340-5p | Down | Act1 | Ischemia/reperfusion |
| miR-374a-5p | Down | MAPK6 | Ischemia/reperfusion |
| miR-429 | Down | MO25 | Ischemia/reperfusion |
| miR-1192 | Down | CASP3 | Myocardial infarction |