Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 May 4;11:574. doi: 10.3389/fphar.2020.00574

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2020 Oddone, Boury, Garcion, Grabrucker, Martinez, Da Ros, Janaszewska, Forni, Vandelli, Tosi, Ruozi and Duskey

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Normalized Cell Index curves of C6 (rat GBM cells) and DI TNC1 (Astrocyte cells). Both types of cells were treated with mPEG-TK-COOH (polymer control), free MPH (11 µM), mPEG-TK-MPH, and mPEG-MPH prodrugs at an equivalent MPH concentration (11 µM) for 48 h. (A) C6 cells. Statistics: One-way ANOVA tests with Bonferroni post-test. Between the dashed lines is indicated the time period in which the differences between treatments are significant and are depicted in the graph (***p ≤ 0.001). Time range: 19.5 h from the addition of the treatments, up to the end of the experiment (48 h). (B) DI TNC1. The significant difference depicted in the graph was calculated considering the full time range from the addition of the different treatments to the end of the experiment (48 h).