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. 2020 May 4;11:574. doi: 10.3389/fphar.2020.00574

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Copyright © 2020 Oddone, Boury, Garcion, Grabrucker, Martinez, Da Ros, Janaszewska, Forni, Vandelli, Tosi, Ruozi and Duskey

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cytotoxicity studies on human GBM cells. (A) U87 MG cells treated with increasing concentration of either free MPH, mPEG-TK-MPH, or mPEG-MPH prodrugs at equivalent MPH concentrations for 48 h. (B) U251 MG cells treated with increasing concentration of either free MPH, mPEG-TK-MPH, or mPEG-MPH prodrugs at equivalent MPH concentrations, for 48 h. Statistics: Two-way ANOVA tests with Bonferroni post-test. Comparisons: mPEG-MPH vs. mPEG-TK-MPH (**p ≤ 0.01 and ***p ≤ 0.001). (C) Co-incubation of U251 MG cells treated with free MPH, mPEG-TK-MPH, or mPEG-MPH prodrugs, with H₂O₂ (100 µM). Statistics: Two-way ANOVA tests with Bonferroni post-Comparisons: mPEG-MPH vs. mPEG-TK-MPH and mPEG-TK-MPH + H₂O₂ (*p ≤ 0.05 and **p ≤ 0.01), mPEG-MPH + H₂O₂ vs. mPEG-TK-MPH and mPEG-TK-MPH + H₂O₂ (⁺p ≤ 0.05 and ⁺⁺p ≤ 0.01), mPEG-MPH or mPEG-TK-MPH (w/and w/o H₂0₂) vs. MPH and MPH + H₂O₂ (^•••p ≤ 0.001).