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. 2020 May 4;11:574. doi: 10.3389/fphar.2020.00574

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Copyright © 2020 Oddone, Boury, Garcion, Grabrucker, Martinez, Da Ros, Janaszewska, Forni, Vandelli, Tosi, Ruozi and Duskey

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Influence of X-ray irradiation on human GBM cells treated with mPEG-TK-MPH and mPEG-MPH. (A) U251 MG cells and (B) U87 MG cells. Statistics: One-way ANOVA tests with Bonferroni post-test. Comparisons: Control vs. mPEG-MPH, mPEG-MPH + 8 Gy, mPEG-TK-MPH and mPEG-TK-MPH + 8Gy (^♦p ≤ 0.05 and ^♦♦♦p ≤ 0.001); mPEG-MPH vs. mPEG-MPH + 8 Gy, mPEG-TK-MPH and mPEG-TK-MPH + 8 Gy (***p ≤ 0.001); mPEG-MPH + 8 Gy vs. 8 Gy, mPEG-TK-MPH and mPEG-TK-MPH + 8Gy (⁺p ≤ 0.05 and ⁺⁺⁺p ≤ 0.001), mPEG-TK-MPH vs. 8 Gy and mPEG-TK-MPH + 8 Gy (^$$$p ≤ 0.001); 8Gy vs. mPEG-TK-MPH + 8Gy (^◦◦◦p ≤ 0.001); MPH and MPH + 8 Gy vs. Control and all other treatments (^•••p ≤ 0.001).