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The structure of the insect circadian clock in mosquitoes and other insects. The positive transcription factors CLOCK (CLK) and CYCLE (CYC) regulate the expression of the core clock genes, period (per), timeless (tim) and cryptochrome2 (cry2), whose respective proteins inhibit the action of CLK and CYC, thereby repressing their own transcription. The TIM protein is degraded by CRY1 in the presence of light (Adapted from [53]).
