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. 2020 Mar 27;2(1):vdaa042. doi: 10.1093/noajnl/vdaa042

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© The Author(s) 2020. Published by Oxford University Press, the Society for Neuro-Oncology and the European Association of Neuro-Oncology.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 3. — Somatic genetic alterations identified in LGG-mIDH-O according to the tumor mutational burden. (A) Upper plot shows the mutation rate for each tumor sample in LGG-mIDH-O^high. Middle plot: Heatmap of the most frequent somatic mutations identified in LGG-mIDH-O^high. Genes are sorted according to the FDR q-value. Lower plot: Mutational signature analysis in LGG-mIDH-O^high samples. (B) Upper plot shows the mutation rate for each tumor sample in LGG-mIDH-O^low. Middle plot: Heatmap of the most frequent somatic mutations identified in LGG-mIDH-O^low. Genes are sorted according to the FDR q-value. Lower plot: Mutational signature analysis in LGG-mIDH-O^low samples. Color codes represent the mutation type or mutation signature as indicated in the left panel.