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. 2020 Feb 28;2(1):vdaa028. doi: 10.1093/noajnl/vdaa028

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© The Author(s) 2020. Published by Oxford University Press, the Society for Neuro-Oncology and the European Association of Neuro-Oncology.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Regions-of-interests used for assessment of normal-appearing brain tissue responses to SRS. (A) A representative co-registered stereotactic dose distribution for a patient with brain metastasis from non-small cell lung cancer as an overlay of a T1-weighted post-contrast image acquired pre-SRS. The prescribed SRS dose was 25 Gy. (B) The dose distribution was divided into 3 dose regions: Reference: <1 Gy (blue overlay), LowDose: 1–10 Gy (green overlay), and HighDose: >10 Gy (yellow overlay). (C) The final regions-of-interest used for longitudinal response assessments included normal-appearing brain tissue, ie, white and gray matter in LowDose (white matter: light green overlay, gray matter: dark green overlay) and HighDose (white matter: light yellow overlay, gray matter: dark yellow overlay), excluding edema (purple overlay) and tumor (red overlay).