Figure 5.

C-terminal truncating mutations are associated with response to depatux-m + TMZ. Deletion of exons 25–27 results in a frame shift of the protein. Such changes are associated with response to depatux-m + TMZ (top right). Nonsense and frameshift mutations show a similar trend (middle panels, left lolliplot of individual mutations, right survival analysis), as do the C-terminal SNVs (bottom panels, left lolliplot of individual mutations, right survival analysis). Hazard rates of individual changes are listed in Table 1.