Table 1.

Niraparib Concentrations in Intracranial SUM149 or MDA-MB-231Br Tumor, Peri-tumor (<2 mm away from tumor), and Contralateral Normal Brain Tissues in Mice Treated With Daily Niraparib by Oral Gavage for 2 Weeks

	Tumor		Peri-tumor		Contralateral normal
Model	Mean	SD	Mean	SD	Mean	SD
SUM149	552.7*	328.5	211.0	56.5	265.3	63.1
MDA-MB-231Br	658.0*	198.1	353.7	164.0	282.0	81.9

Concentrations are normalized as nanogram niraparib per gram of tissue as assessed by HPLC with positive ESI MS.

*Tumor concentrations where significantly higher than peri-tumor (P < .03) and contralateral normal (P < .02) tissue, n = 3 per group.