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. 2020 May 4;11:550. doi: 10.3389/fphar.2020.00550

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Copyright © 2020 Brewer, Kuenze, Vanoye, George, Meiler and Sanders

This is an open-access article distributed under the tes of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The selectivity filters of K⁺ and Na⁺ channels. (A) Multiple sequence alignment of the SF region of selected K⁺ (left) and Na⁺ (right) channels. Conserved amino acids are highlighted in bold. Amino acids belonging to the DEKA signature motif in eukaryotic Na⁺ channels are colored red. (B) Side and top view of the SF of human KCNQ1 (PDB: 6UZZ) (Sun and Mackinnon, 2020). Two subunits are omitted for clarity in the left plot. (C) Side and top view of the SF of SCN5A (PDB: 6UZ3) (Jiang et al., 2020). Repeat II is omitted for clarity in the left plot.