Table 2.
Demographic Characteristics of Patients With Ependymoma Categorized by Children, Adolescents, Young Adults, and Older Adults, 1975–2016 (n = 6076)
| Total | Children (0–12), n (%) | Adolescents (13–21), n (%) | Young adults (22–45), n (%) | Older adults (>45), n (%) | P | |
|---|---|---|---|---|---|---|
| N = 6076 | N = 1111 (18.3) | N = 529 (8.7) | N = 2039 (33.6) | N = 2397 (39.5) | ||
| Mean age in years (standard deviation) | 4.5 (3.7) | 16.9 (2.7) | 34.2 (6.8) | 59.0 (9.8) | ||
| Gender | .103 | |||||
| Female | 2800 | 504 (45.4) | 221 (41.8) | 936 (45.9) | 1139 (47.5) | |
| Male | 3276 | 607 (54.6) | 308 (58.2) | 1103 (54.1) | 1258 (52.5) | |
| Race | <.001 | |||||
| White | 5121 | 872 (78.5) | 437 (82.6) | 1715 (84.1) | 2097 (87.5) | |
| Non-white | 955 | 239 (21.5) | 92 (17.4) | 324 (15.9) | 300 (12.5) | |
| Anatomical location of the tumor | <.001 | |||||
| All supratentorial brain, overlapping lesion of brain, and brain, not otherwise specified (NOS) | 1116 | 458 (41.2) | 140 (26.5) | 243 (11.9) | 275 (11.5) | |
| Spinal cord, spinal meninges, cerebral meninges, and cauda equina | 3323 | 106 (9.5) | 254 (48.0) | 1371 (67.2) | 1592 (66.4) | |
| Posterior fossa, cerebellum, and brainstem | 1083 | 391 (35.2) | 90 (17.0) | 266 (13.0) | 336 (14.0) | |
| Ventricles | 540 | 156 (14.0) | 44 (8.3) | 152 (7.5) | 188 (7.8) | |
| Cranial nerves and other | 14 | 0 (0.0) | 1 (0.2) | 7 (0.3) | 6 (0.3) | |
| Type of surgery | <.001 | |||||
| No surgery | 402 | 38 (3.4) | 23 (4.3) | 114 (5.6) | 227 (9.5) | |
| Biopsy | 2031 | 196 (17.6) | 164 (31.0) | 755 (37.0) | 916 (38.2) | |
| STR | 533 | 96 (8.6) | 48 (9.1) | 159 (7.8) | 230 (9.6) | |
| GTR | 1377 | 275 (24.8) | 124 (23.4) | 484 (23.7) | 494 (20.6) | |
| Surgery, NOS | 64 | 3 (0.3) | 9 (1.7) | 27 (1.3) | 25 (1.0) | |
| Unknown | 19 | 3 (0.3) | 1 (0.2) | 3 (0.1) | 12 (0.5) | |
| Radiation | <.001 | |||||
| No radiation | 3816 | 428 (38.5) | 261 (49.3) | 1382 (67.8) | 1745 (72.8) | |
| Radiation | 2260 | 683 (61.5) | 268 (50.7) | 657 (32.2) | 652 (27.2) | |
| All-cause mortality | <.001 | |||||
| Alive | 4462 | 696 (62.6) | 440 (83.2) | 1692 (83.0) | 1634 (68.2) | |
| Died | 1614 | 415 (37.4) | 89 (16.8) | 347 (17.0) | 763 (31.8) | |
| Grade | <.001 | |||||
| Well differentiated | 326 | 38 (3.4) | 28 (5.3) | 134 (6.6) | 126 (5.3) | |
| Moderately differentiated | 656 | 68 (6.1) | 50 (9.5) | 241 (11.8) | 297 (12.4) | |
| Poorly differentiated | 120 | 55 (5.0) | 9 (1.7) | 29 (1.4) | 27 (1.1) | |
| Undifferentiated | 579 | 309 (27.8) | 65 (12.3) | 105 (5.1) | 100 (4.2) | |
| Unknown | 4395 | 641 (57.7) | 377 (71.3) | 1530 (75.0) | 1847 (77.1) | |
| Histology | <.001 | |||||
| Ependymoma, NOS | 4126 | 671 (60.4) | 301 (56.9) | 1396 (68.5) | 1758 (73.3) | |
| Ependymoma, anaplastic | 766 | 395 (35.6) | 88 (16.6) | 141 (6.9) | 142 (5.9) | |
| Papillary ependymoma | 60 | 5 (0.5) | 6 (1.1) | 24 (1.2) | 25 (1.0) | |
| Myxopapillary ependymoma | 1124 | 40 (3.6) | 134 (25.3) | 478 (23.4) | 472 (19.7) |
Chi-square tests used for categorical variables.
*Statistical significants of P value < 0.05.