Table 1.
List of Most Prominent Suicide Gene Therapy Systems Used for HGG Treatment
| Suicide Gene | Origin of Suicide Gene | Prodrug/Drug | PMID |
|---|---|---|---|
| HSV-TK | Viral | GCV/GCV-TP | 19617915 |
| VZV-TK | Viral | GCV/GCV-TP | 9231072 |
| Tomato-TK | Viral | AZT/AZT-TP | 20154339 |
| EHV4-TK | Viral | GCV/GCV-TP | 12489026 |
| Cytosine deaminase | Bacterial and yeast | 5-FC/5-FU | 23969884 |
| Purine nucleoside phosphorylase (PNP) | Bacterial | MeP-dR/MEP | 15374975 |
| Nitroreductase | Bacterial | CB1954/AHNB | 27840931 |
| Guanine phosphorybosyl transferase | Bacterial | 6TX/6GMP | 9414253 |
| Carboxylesterases (CE) | Mammalian | IRT/SN-38 | 24167321 |
| Cytochrome P450 | Mammalian, rodent | CPA/PM | 9354446 |
While some suicide genes are compatible with several prodrugs, only one representative prodrug along with the corresponding toxic drug is mentioned here.
GCV-TP, GCV triphosphate; MeP-dR, 9-β-d-[2–deoxyribofuranosyl]-6-methylpurine; MEP, 6-methylpurine; CB1954, 5-aziridinyl-2,4-dinitrobenzamide; AHNB, 5-(aziridinyl)-4-hidroxylamine-2-nitrobenzamide; IRT, irinotecan; 6TX, 6-thioxanthine; 6GMP, 6-thioguanine monophosphate; CPAC, cyclophosphamide; PM, phosphoramide mustard.