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. 2019 May 28;1(1):vdz004. doi: 10.1093/noajnl/vdz004

Fig. 5.

Fig. 5

Safety profile of the convection-enhanced delivery (CED) of ZSTK474 and trametinib. Animals were Killed 48 hours after the last CED injection of either vehicle (A) or combination of both ZSTK474 and trametinib (B). No difference was observed in histology across treatments. Further animals were killed 2 weeks after the last CED injection of either vehicle (C) or combination of both ZSTK474 and trametinib (D). No difference was observed in histology across treatments. Scale bars as 1 mm and 125 µm, as indicated.