Table 1.
Demographic and Clinical Data by Tertiles of Plasma APOC-III Levels
| Clinical Variables | Low (n = 65) | Middle (n = 65) | High (n = 65) | P value |
|---|---|---|---|---|
| Age, y | 75.2 ± 6.63 | 75 ± 6.65 | 74.7 ± 7.49 | 0.9 |
| Education, y | 16.3 ± 2.92 | 16.1 ± 2.82 | 15.3 ± 2.96 | 0.1 |
| Female, n (%) | 18 (27.7) | 23 (35.4) | 28 (43.1) | 0.186 |
| APOE4, n (%) | 26 (40) | 26 (40) | 31 (47.7) | 0.59 |
| MMSE scores | 27.4 ± 1.86 | 27.5 ± 1.55 | 27.3 ± 2.15 | 0.97 |
| CSF Aβ42, pg/mL | 188 ± 57.2 | 177 ± 57.2 | 181 ± 62.2 | 0.6 |
| CSF t-tau, pg/mL | 84.6 ± 42.6 | 103 ± 57.2 | 97.5 ± 48.1 | 0.09 |
| CSF p-tau, pg/mL | 31.1 ± 13.8 | 33.6 ± 16.7 | 32.9 ± 16 | 0.8 |
| Plasma APOC-III, µg/mL | 2 (0.08) | 2.15 (0.04)a | 2.32 (0.08)b,c | <0.001 |
| Follow-Up Visits, n Subjects | ||||
| Baseline | 65 | 65 | 65 | |
| 1 y | 65 | 65 | 65 | |
| 2 y | 19 | 24 | 19 | |
| 3 y | 16 | 19 | 15 | |
| 4 y | 12 | 11 | 18 | |
| 5 y | 6 | 7 | 8 | |
| 6 y | 2 | 3 | 5 | |
| 7 y | 0 | 2 | 0 |
Notes: Comparison between tertile 1 and tertile 2 is marked behind “tertile 2”, ap < 0.05. Comparison between tertile 1 and tertile 3 is marked behind “tertile 3”, bp < 0.05. Comparison between tertile 2 and tertile 3 is marked behind “tertile 3”, cp < 0.05.
Abbreviations: MMSE, Mini-Mental State Examination; APOC-III, apolipoprotein C-III; Aβ42, β- amyloid 42; t-tau, total tau; p-tau, phosphorylated tau