Table 2.

Summary of Linear Mixed Models Examining the Associations of Plasma APOC-III with Changes in CSF AD Pathologies

Dependent Variable: CSF Aβ42
Predictors	Estimate	SE	P value
Middle APOC-III × time	−0.2453	0.9750	0.8013
High APOC-III × time	1.9053	0.9568	0.0464
Dependent Variable: CSF t-tau
Predictors	Estimate	SE	P value
Middle APOC-III × time	0.6904	1.2410	0.5780
High APOC-III × time	−0.5342	1.2334	0.6649
Dependent Variable: CSF p-tau
Predictors	Estimate	SE	P value
Middle APOC-III × time	0.1225	0.8038	0.8788
High APOC-III × time	0.4625	0.7889	0.5577

Note: The bold value indicates a statistically significant difference with a p-value < 0.05. Estimates are unstandardized values, representing the amount of change in each CSF AD biomarker per year. All linear mixed models were adjusted for age, education, sex and APOE4 genotype.

Abbreviation: APOC-III, apolipoprotein C-III; Aβ42, β-amyloid 42; t-tau, total tau; p-tau, phosphorylated tau.