Table 2.

Rescue Treatment to break the pain cycle in migraine

Drug		Strength and dosage schedule	Max dose per day	Side effects
Acetaminophen	Paracetamol Paracetamol domperidone combination	500 mg/650 mg TID × 7 days 500 mg + 10 mg TID × 3 days	1500 mg/ 1950 mg 1500 + 30 mg	Nausea, stomach pain, jaundice
NSAIDs	Ibuprofen Indomethacin Ketorolac Naproxen Naproxen domperidone combination Nabumetone Diclofenac Mefenamic acid	400 mg TID × 3-5 days 50 mg TID × 7 days 10 mg TID × 3 days. 500 mg BID × 5-14 days 500 mg + 10 mg TID × 3 days 500 mg BID × 7 days 50 mg BID × 3-5 days 250 mg TID × 3-5 days	1200 mg 150 mg 30 mg 1500 1500 + 30 mg 1000 100 750	Heartburn, stomach pain, tinnitus, dizziness, allergic reaction, high BP
Neuroleptics	Prochlorperazine Promethazine Metoclopramide Chlorpromazine	5-10 mg TID × 3 days. 12.5-50 mg TID × 3 days. 5-10 mg TID × 3 days. 25 mg TID × 3 days.	30 mg 150 mg 30 mg 75 mg	Dizziness, somnolence, extrapyramidal symptoms, prolong QT interval
Long acting triptans	Frovatriptan Naratriptan	2.5 mg BID × 3 days. 1 mg or 2.5 mg, BID × 3 days.	5 mg 5 mg	Generally safe but occasionally can cause. Tingling, flushing, sense of fullness in head, neck, and chest, somnolence. Contraindicated in coronary insufficiency, untreated hypertension, ischemic stroke, peripheral vascular disease, pregnancy
Antiepileptics	Valproic Acid	500-1000 mg qhs × 5 days	1000 mg	Contraindicated in woman of child bearing potential. Somnolence, hyperammonemia, tremor, liver dysfunction