Table 1.

Direct-acting oral anticoagulants (DOACs) and reversal

DOAC	Brand name	Mechanism of action	Time to onset	t1/2	Reversal
Dabigatran	Pradaxa	Direct thrombin inhibitor	0.5–2 hour	15 hours	Idarucizumab
Rivaroxaban	Xarelto	Factor Xa inhibitor	2–4 hour	6–12 hour	3F- and 4F-PCC, andexanet alfa
Apixaban	Eliquis		1–2 hour
Edoxaban	Savaysa, Lixiana		1–2 hour		Andexanet alfa
Betrixaban	Bevyxxa		3–4 hour	24 hours