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. 2020 May 11;21:110. doi: 10.1186/s12931-020-01373-5

Table 1.

The model of acute lung diseases in the various animal species and treatment using the MSCs

The method of inflammation The causative agent of inflammation Animal species The method of cell transplantation Dose of the cell Source of the cell Type of the cell
[30] Intratracheal LPS Mice Intravenous 2.5 × 105 Bone marrow of mice MSCs
[53] Intrperitoneal LPS Mice Intravenous 5 × 105 Bone marrow of mice MSCs
[28] Intratracheal LPS Mice Intratracheal 7.5 × 105 Bone marrow of mice MSCs
[54] Intratracheal E.coli Mice Intratracheal 106 Bone marrow of humman MSCs
[49, 55] Intravenous LPS Rat Intravenous 106 Bone marrow of rat MSCs
[56] Intratracheal LPS Mice Intratracheal 106 Umbilical cord of humman MSCs
[57] Intratracheal E.coli Mice Intratracheal 105 Umbilical cord of humman MSCs
[58] Aspiration LPS Mice Aspiration 5 × 105 Bone marrow of humman MSCs
[50] Intrperitoneal LPS Mice Intravenous 5 × 105 Umbilical cord of humman MSCs
[59] Intratracheal E.coli Mice Intratracheal 7.5 × 105 Bone marrow of mice MSCs
[60] Intratracheal LPS Rat Intrapleural 106 Bone marrow of rat MSCs
[51] Intravenous Oleic acid Rat Intravenous 2 × 105 Bone marrow of rat MSCs
[61] Intratracheal LPS Mice Intravenous 5 × 105 Bone marrow of mice MSCs
[38] Intratracheal LPS Mice Intratracheal 2.5 × 105 Bone marrow of mice MSCs
[62] Intratracheal or Intrperitoneal LPS Mice Intravenous 105 Bone marrow of mice MSCs
[63] Ventilation Ventilator Rat Intratracheal or Intravenous 4 × 105 Bone marrow of rat MSCs
[64, 65] Intranasal LPS Mice Intravenous 106 Adipose tissue of humman MSCs
[66] Intratracheal LPS Mice Intravenous 5 × 105 Bone marrow of mice MSCs
[67] Intratracheal E.coli Mice Intravenous 5 × 105 Bone marrow of mice MSCs
[68] Intrperitoneal LPS Mice Intravenous 5 × 105 Bone marrow of mice MSCs
[36] Intratracheal Smoke Sheep Intravenous 10 × 106 Bone marrow of humman MSCs
[69] Intratracheal LPS Mice Intravenous 5 × 105 Bone marrow of mice MSCs
[70] Intrperitoneal LPS Mice Intravenous 5 × 105 Bone marrow of mice MSCs
[71] Intratracheal LPS Mice Intratracheal 7.5 × 105 Bone marrow and embryonic of human MSCs
[72] Intratracheal E.Coli Rat Intratracheal

2 × 106

5 × 106

1 × 107

2 × 107

Bone marrow of human MSCs
[52] Intranasal H9N2 avian influenza virus Mice Intravenous 105 Bone marrow of mice MSCs
[48] Aspiration Stomach contents Rat Intravenous 5 × 106 Bone marrow of mice MSCs
[27] Intratracheal LPS Mice Intravenous 0.5 × 106 Umbilical cord of human MSCs
[37] Intravenous Oleic acid Pig Intravenous 2 × 106 Bone marrow of human MSCs
[35, 73] Intratracheal LPS Mice Intravenous 106 Menstrual blood MSCs
[74] Intratracheal LPS Mice retro-orbital injection 5 × 105 Adipose tissue of mice MSCs
[31] Intratracheal LPS Sheep Intratracheal 5 × 107 Bone marrow of sheep MSCs
[5] Intratracheal LPS Rabbit Intratracheal 107 Bone marrow of rabbit MSCs