Table 1.
Details of Maternal Infection, Prenatal Course, Delivery, and Immediate Neonatal Course Among Four Twin Pregnancies Complicated by Antenatal Exposure to ZIKV Infection
| Twin Pair | Maternal Symptoms | WGA at Diagnosis | Maternal ZIKV PCR | WGA at Delivery | Twin | Neonatal ZIKV PCR | Placental ZIKV PCR | BW (Grams) | NICU Admission | Abnormal Neonatal Outcome |
|---|---|---|---|---|---|---|---|---|---|---|
| Twin pair 1 | Y | 24 | + (serum) | 37 | Twin A | + | + | 2400 | N | N |
| Twin B | + | – | 2590 | N | N | |||||
| Twin pair 2 | Y | 33 | – | 34 | Twin A | + | + | 2190 | N | Y – abnormal BERA at 1 week of life |
| Twin B | + | + | 2240 | N | Y – abnormal BERA at 1 week of life | |||||
| Twin pair 3 | Y | 16 | + (urine) | 35 | Twin A | + | + | 2550 | Y | Y – TFUS with grade 1 IVH |
| Twin B | – | – | 2650 | N | N | |||||
| Twin pair 4 | Y | 21 | + (urine) | 35 | Twin A | N/A | – | 2490 | N | Na |
| Twin B | N/A | – | 2220 | N | Na |
Abbreviations: BERA, brainstem evoked response audiometry; BW, birth weight; IVH, intraventricular hemorrhage; N, no; NICU, neonatal intensive care unit; PCR, polymerase chain reaction; TFUS, transfontanellar ultrasound; WGA, weeks gestational age; Y, yes; ZIKV, Zika virus.
aThese twins did not receive the detailed postnatal examination for suspected antenatal ZIKV exposure, but there were no gross physical or developmental abnormalities noted in the immediate neonatal period.