FIGURE 2.

Changes in bronchoalveolar lavage (BAL)-microRNA (miRNA) levels are associated with pneumonia or clinical acute rejection (c-AR). The time-dependent interaction of BAL-miRNAs with presence of pneumonia (A) or c-AR (B) was analyzed by nonparametric repeated-measures ANOVA with correction for multiple comparisons (see also Table S8, SDC, http://links.lww.com/TXD/A248). This analysis was performed using the first series of patients (n = 16; see also Figure S1, SDC, http://links.lww.com/TXD/A248). miRNAs whose levels were significantly elevated at T2 are shown. C, Vulcano plot showing the biological processes potentially affected by c-AR-miRNAs. Target prediction was performed using the miRTargetLink Human tool, and gene lists were annotated using WebGestalt and GeneOntology as functional database. FDR, false discovery rate; RQ, relative quantity.