Table 5. Parameter values (relative to baseline O’Hara-Rudy model [1,2]) of Patient 9 models derived via GA or via comparison of mRNA levels to reference patient.
| Reference patient | Patient 8 (mRNA-rescaled model) | Patient 9 (GA-optimized model) | Patient 10 (mRNA-rescaled model) |
|---|---|---|---|
| IK1 | 0.457 | 0.283 | 0.618 |
| IKr | 1.226 | 1.002 | 0.806 |
| IKs | 0.149 | 0.143 | 0.306 |
| INa | 0.989 | 2.542 | 0.550 |
| Ito | 8.218 | 9.743 | 4.227 |
| ICaL | 0.606 | 0.830 | 0.405 |
| INCX | 2.991 | 1.772 | 1.459 |
| INaK | 4.136 | 1.220 | 3.353 |
| IpCa | 1.066 | 0.170 | 0.307 |
| SERCA | 4.690 | 2.227 | 3.436 |
| CaM | 10.112 | 3.762 | 1.739 |
| RyR | 0.825 | 0.690 | 0.470 |
| CaMKII | 0.163 | 0.211 | 0.902 |