Table 2. Comparisons of hemodynamic and cardiovascular MRI variables between patients with normal SVR at 6 months (SVR-), those with abnormal SVR only at 6 months (SVR+) and those with abnormal SVR both at baseline and 6 months (SVR++).
| Baseline variables | 6-month variables | |||||||
|---|---|---|---|---|---|---|---|---|
| SVR- (n = 90) | SVR+ (n = 10) | SVR++ (n = 21) | P value | SVR- (n = 90) | SVR+ (n = 10) | SVR++ (n = 21) | P value | |
| Heart rate (bpm) | 64 (57–72) | 67 (61–73) | 62 (59–71) | 0.70 | 58 (52–62) | 55 (53–57) | 55 (53–61) | 0.38 |
| Systolic blood pressure (mmHg) | 125 (110–139) | 111 (101–126) | 138 (123–149)† | 0.019 | 124 (115–134) | 129 (122–143) | 150 (140–163)* | < 0.001 |
| Diastolic blood pressure (mmHg) | 73 (65–82) | 65 (61–70) | 79 (73–85)† | 0.005 | 68 (63–75) | 76 (66–84) | 80 (72–90)* | < 0.001 |
| Mean blood pressure (mmHg) | 90 (81–102) | 83 (75–89) | 99 (91–105)† | 0.005 | 86 (80–95) | 93 (84–105) | 104 (95–114)* | < 0.001 |
| LV ejection fraction (%) | 43 (37–48) | 42 (33–49) | 43 (39–47) | 0.91 | 51 (45–56) | 42 (37–50)* | 49 (44–52) | 0.034 |
| LV end-diastolic volume (mL.m-2) | 94 (83–105) | 92 (86–104) | 82 (69–87)*† | < 0.001 | 99 (85–107) | 88 (83–100) | 87 (75–92)* | 0.005 |
| LV end-systolic volume (mL.m-2) | 53 (44–63) | 54 (46–63) | 45 (39–51)* | 0.004 | 47 (39–58) | 50 (43–61) | 43 (35–50) | 0.21 |
| LV mass (g.m-2) | 55 (49–60) | 53 (49–58) | 52 (47–56) | 0.39 | 46 (42–52) | 43 (39–48) | 46 (41–49) | 0.46 |
| LV concentric remodeling index | 0.58 (0.53–0.64) | 0.56 (0.54–0.58) | 0.63 (0.58–0.73)* | 0.029 | 0.47 (0.42–0.53) | 0.49 (0.41–0.53) | 0.56 (0.52–0.59)* | 0.003 |
| MI volume at MRI (% of LV) | 21 (12–31) | 26 (7–34) | 22 (13–28) | 0.87 | 13 (7–24) | 20 (7–28) | 12 (10–19) | 0.66 |
| Microvascular obstruction (% of LV) | 2 (0–9) | 4 (0–12) | 0 (0–9) | 0.82 | _____ | _____ | _____ | _____ |
| Stroke volume index (mL.m-2) | 39.7 (34.0–43.9) | 38 (32–43) | 33.8 (28.2–37.0)* | 0.003 | 48.6 (44.8–53.9) | 42.4 (34.3–45.2)* | 38.6 (32.1–45.4)* | < 0.001 |
| Cardiac index (L.min-1.m-2) | 2.52 (2.18–2.82) | 2.41 (2.31–2.67) | 2.22 (1.96–2.31)*† | 0.002 | 2.70 (2.47–3.12) | 2.12 (1.94–2.38)* | 2.14 (1.92–2.47)* | < 0.001 |
| SVR (mmHg.min.m2.L-1) | 36.7 (31.1–42.8) | 34.1 (29.8–35.8) | 44.5 (42.9–47.7)*† | <0.001 | 31.8 (28.2–35.4) | 42.4 (40.7–48.7)* | 48.5 (43.9–52.1)* | <0.001 |
LV, left ventricle; MI, myocardial infarction; NS, non significant with a p value < 0.10; SVR, systemic vascular resistance
*: p<0.05 for comparisons of SVR+ or SVR++ vs. SVR-, and
†: p<0.05 for comparisons of SVR++ vs. SVR+ at the same time point (baseline or 6 months).