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. Author manuscript; available in PMC: 2020 May 11.
Published in final edited form as: Oncogene. 2008 Dec 8;28(6):792–802. doi: 10.1038/onc.2008.437

Figure 4.

Figure 4

Matching expression patterns of phospho-ERM and phospho-PKCα in metastatic lesions. Immunohistochemistry detection of phosphorylated ERM and phospho-PKCα in K7M2 murine osteosarcoma lung nodules (harvested 24 days after cell injection to mice). Adjacent lung sections were labeled with antibodies against either phospho-PKCα (Ser 657) (a–c) or phospho-ERM (d–f). Phospho-PKCα (a and b) and phospho-ERM (d and e) immunoreactivity was evident at the periphery of metastatic lesions. Both active PKCα expression and phosphorylated ERM expression was low in the central portions of the metastatic lesions (Figures 4c and f). Bar = 200 μm in low magnification photographs and 50 μm in high magnification photographs.