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Relative methylation activities of CGI and non-CGI targets for hypermethylated and hypomethylated DMTs. This plot, adjusted for the greater methylation preload of non-CGI targets, reflects a roughly 2-fold greater CGI hypermethylation versus non-CGI hypermethylation, equivalent non-CGI hypomethylation and hypermethylation, and significant deficit of CGI demethylation in FL.
