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. 2020 Mar 26;5(6):e133429. doi: 10.1172/jci.insight.133429

Figure 1. Semaglutide in obese rodents.

Figure 1

(A and B) BW and food intake in DIO mice treated twice daily (n = 9). (C−H) BW, EE, food intake, and RER in DIO mice treated once daily (n = 8). *P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001 semaglutide (sema) vs. vehicle and #P < 0.05, ##P < 0.01, and ###P < 0.001 sema vs. weight-matched, mixed-effects model, Tukey’s post hoc. (I−K) BW and food preference in DIO rats treated once daily (n = 13–14). *P < 0.05, **P < 0.01, and ***P < 0.001 vs. vehicle, 1-way ANOVA, Dunnett’s post hoc. Data are individual measures with mean ± SEM. Animals were subject to a 12-hour light/12-hour dark cycle. RER, respiratory exchange ratio; sema, semaglutide.