Figure 3. IAP supplementation extends lifespan in mice.

(A) Survival of IAP-KO, WT, and IAP-supplemented mice (20 WT, 14 IAP-KO, and 6 IAP-supplemented mice). (B and C) Clinical frailty index of WT and IAP-KO mice (B) and vehicle- or IAP-supplemented WT mice (C). Unpaired Student t tests or ANOVA with multiple-comparisons post hoc tests (Tukey’s HSD) were used as statistical tests. Survival data were compared using the log-rank significance test.*P < 0.05, **P < 0.01.