Table 1.
Characteristics of Gen3G mother-child pairs included in maternal insulin sensitivity EWAS of placenta
| Mothers (N) | 430 |
| Age (years) | 28 (25; 31) |
| Ethnicity, European descent | 430 (100.0) |
| Gravidity, 1st pregnancy | 142 (33.0) |
| Parity, 1st term pregnancy | 218 (50.7) |
| Smoking in early pregnancy | 36 (8.4) |
| BMI in early pregnancy (kg/m2) | 23.7 (21.6; 27.9) |
| Waist circumference at 1st-trimester visit (cm) | 89.1 [82.0; 97.0] |
| Blood pressure at 2nd-trimester visit (systolic/diastolic mmHg) | 107/67 (100/63; 112/72) |
| OGTT (2nd trimester) | |
| Fasting glucose (mmol/L) | 4.2 (3.9; 4.4) |
| 1-h glucose (mmol/L) | 7.1 (6; 8.2) |
| 2-h glucose (mmol/L) | 5.7 (4.8; 6.6) |
| Insulin sensitivity, Matsuda index (raw) | 7.72 (5.69; 10.67) |
| Insulin sensitivity, Matsuda index (natural log transformed) | 2.04 (1.74; 2.37) |
| GDM* | 37 (8.6) |
| Children | |
| Gestational age at birth (weeks) | 39.7 (38.9; 40.4) |
| Female sex | 204 (47.4) |
| Birth weight (kg) | 3.44 (3.17; 3.71) |
| Large for gestational age, >90th percentile | 31 (7.2) |
| Placental weight (g) | 542 (467; 642) |
Data are median (IQR) or n (%) unless otherwise indicated.
*
GDM was diagnosed according to International Association of the Diabetes and Pregnancy Study Groups.