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. 2020 May 7;13:3853–3866. doi: 10.2147/OTT.S232918

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© 2020 Liu and Wang.

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OIP5-AS1 knockdown enhanced CDDP sensitivity in MG63/CDDP and Saos-2/CDDP cells. (A–I) The MG63/CDDP and Saos-2/CDDP cells were transfected with si-NC or si-OIP5-AS1. (A) The level of OIP5-AS1 was detected via qRT-PCR. (B–D) The IC₅₀ value of CDDP was measured via CCK-8 assay. (E–F) The cell viability was tested by CCK-8 assay. (G) The apoptotic rate was assessed through flow cytometry. (H and I) The protein levels of MRP1, P-gp, Bcl-2, Bax, and cleaved-caspase-3 were evaluated via Western blot assay. *P<0.05.